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Cardiovascular (CV) disease is a leading cause of death worldwide, with unique disease burden in East Asians. However, Asian cohort of CV disease is insufficient. Therefore, a prospective, multicenter observational registry study, Taiwanese Secondary Prevention for patients with AtheRosCLErotic disease (TSPARCLE) Registry, has been run since 2010 to document treatment and outcome of CV disease in Taiwan. We identified several region-specific issues, including treatment patterns, general and residual risk factors, which might be valuable for guiding patient care.