Abstract

Objective: To compare the oxygenation level and clinical effect of THRIVE at different flow rates and nasal catheter ventilation in geriatrics undergoing painless gastrointestinal endoscopy.

Methods: This study involved geriatrics undergoing painless digestive endoscopy at Shenzhen Hospital (Futian) of Guangzhou University of Traditional Chinese Medicine from January to December 2023. Participants were randomly divided into three groups: N (nasal catheter, 60 cases), Th1 (THRIVE 10L, 60 cases), and Th2 (THRIVE 20L, 60 cases). SpO2, MAP, and HR were measured at T0 (pre-induction), T1 (5 min after induction), T2 (during operation), and T3 (post-operation). Safe apnea time, mechanical ventilation rate, respiratory depression rate, satisfaction, recovery time, and incidence of adverse reactions like dizziness, nausea, and vomiting were also recorded.

Results: There were no significant differences in HR and MAP across groups (p > 0.05). SpO2 was higher in Th1 and Th2 groups than in N group at T1, with Th2 showing the highest levels at T1, T2, and T3 (p < 0.05). Th1 and Th2 groups had longer safety time, lower mechanical ventilation, respiratory depression rates and lower patients' satisfaction compared to N group (p < 0.05). Recovery time was shorter in Th1 and Th2, with no difference in doctor satisfaction between groups (p > 0.05). There were no significant differences in nausea, vomiting, or postoperative dizziness (p > 0.05).

Conclusion: THRIVE for geriatrics undergoing gastrointestinal endoscopy can not only improve the oxygenation state, but also effectively reduce the incidence of respiratory depression and mechanical ventilation, shorten the recovery time, and decrease the rate of postoperative nausea and vomiting. This method may provide convenience for anesthesiologists in the intraoperative management.