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Human protothecosis is a rare disease that predominantly occurs in immunocompromised patients. Here, we present a case of a 73-year-old man with cutaneous protothecosis. The patient had multiple comorbidities and dermal exposure to herbs. Conventional and molecular diagnostic techniques revealed that the causative agent of protothecosis in this patient was Prototheca wickerhamii. Currently, no standard treatment is available for protothecosis. The patient achieved clinical improvement through voriconazole treatmen