Supplementary Material

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Background: Endoscopic ultrasound with fine needle biopsy (EUS-FNB) is the most useful procedure to obtain tissue samples for confirmation of pancreaticobiliary disease. It was a relative mini-invasive procedure had low complication rate in overall patients. However, there was no study to observe the safety and effectiveness of EUS-FNB in elderly patients.

Methods: We compared the clinical which including the Charlson comorbidity index (CCI) and antithrombotic agents using in elderly patients, tumor factors and EUS characteristics between elderly and younger patients who underwent EUS-FNB in our hospital.

Results: Total we enrolled 41 elderly patients ≥ 70 years old who underwent EUS-FNB between April 2019 to January 2021. Most of the elderly patients had high Charlson comorbidity index, and there were 29.3% patients using antithrombotic agents. There were no significant differences in adverse events or cytopathological diagnostic rate between younger and elderly patients.

Conclusion: EUS-FNB is a safe and effective diagnostic procedure for elderly patients, even for those with comorbidities or who use antithrombotic agents.