International Journal of Gerontology
Volume 16, Issue 3
Focus: COVID-19 Management
Rethinking the Immune Regulatory Role of Platelets during the COVID-19 Pandemic
Su YW, Kuo YS, Chang MC. Rethinking the Immune Regulatory Role of Platelets during the COVID-19 Pandemic. Int J Gerontol. 2022;16(3):167-174.
Supplementary MaterialNo data
KeywordCOVID-19 inflammation platelet SARS-CoV-2
Since the start of the COVID-19 pandemic, the recognition and management of thrombotic complications has become a clinical challenge, either in severe cute respiratory syndrome coronavirus 2 (SARSCoV-2) patients or in those receiving vector-based COVID-19 vaccination. In addition to blood clot formation, platelets can also respond to a variety of inflammatory cytokines and act in concert with circulating leukocytes to prevent pathogen infection. Herein, we review the basic biological roles of platelets in infection/inflammation, tools for assessment, and mechanisms of platelet activation to elucidate their immune regulatory roles.