Supplementary Material

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The purpose of this study was to verify longitudinal changes in motor and muscle function in senescence-accelerated mice using behavioral tests. Wire hanging tests (WHT) were performed on senescence-accelerated mouse prone 1 (SAMP1) and senescence-accelerated mouse resistant 1 (SAMR1), from the age of eight weeks to 44 weeks. In WHT, the hanging time of SAMP1 was lower than that of SAMR1 in eight-week-old to 44-week-old mice. The hanging time of SAMR1 decreased with age, however, this change was hardly observed in SAMP1. In addition, there was no difference in body weight between strains at each week. However, the weights of the soleus, plantaris, and gastrocnemius muscles in SAMP1were lower than those in SAMR1 at 44weeks of age. These results suggest that the motor and muscle function of SAMP1 is lower than that of SAMR1, and it is possible that the lower muscle weight contributes to lower motor and muscle function of SAMP1.