Abstract

Background: Coronary artery disease (CAD) is the leading cause of death worldwide. However, the correlation between the atherogenic index of plasma  (AIP), triglyceride-glucose index (TyG), and γ-glutamyl transpeptidase (γGT) with subclinical CAD across different age groups in the Taiwanese population
remains unclear.

Methods: This cross-sectional study enrolled 901 participants aged 50-75 years. Medical history taking, physical examination, blood tests, and coronary computed tomography angiography (CCTA) were performed during health checkups. AIP, TyG, and γGT levels were determined. The participants were  divided into two groups based on CCTA: those without subclinical CAD and those with subclinical CAD.

Results: Multiple logistic regression analysis suggested that γGT and TyG levels were independently associated with subclinical CAD. Furthermore, γGT was observed to be the only factor independently associated with subclinical CAD in older participants (OR: 1.617, 95% CI: 1.079–2.424, p = 0.020). In  comparison, TyG was the only independent factor associated with subclinical CAD in middle-aged participants (OR: 1.323, 95% CI: 1.021–1.714, p = 0.034).

Conclusions: The study results show that AIP, TyG, and γGT can be regular monitoring indices for assessing the risk of subclinical CAD. Additionally, γGT may  be more suitable for older persons, while TyGmay be more suitable for middle-aged persons.