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Mucormycosis, also known as black fungus, is a rare fungal infection that has high morbidity and mortality even with early diagnosis and treatment.  Hematological malignancy, trauma, and poorly-controlled diabetes mellitus are known risk factors for mucormycosis. Rhino-orbito-cerebral mucormycosis is the most common clinical presentation, and amphotericin B and posaconazole are often used for mucormycosis treatment. Posaconazole has been associated with acute drug induced liver injury in some cases. Hence, isavuconazole is an alternative choice.We present a case of rhino mucormycosis in a 65-year-old man with uncontrolled diabetes mellitus. He developed acute liver injury after posaconazole exposure and was subsequently treated successfully with isavuconazole.